prof. dr hab. Moraczewska JoannaPublikacje

prof. dr hab. Moraczewska JoannaPublikacje

Oryginalne prace doświadczalne:

  1.  Jerzmanowski, A., Moraczewska, J. (1987) A charged contaminant prevents Physarum chromatin from aggregating. Biochim.Biophys.Acta 910, 111-115.
  2. Jerzmanowski, A., Moraczewska, J. (1988) Distribution of postsynthetic methylation sites in Physarum histone H1. Mol.Biol.Rep.13, 97-101.
  3. Strzelecka-Gołaszewska, H., Boguta, G., Zmorzyński, S., Moraczewska, J. (1989) Biochemical and theoretical approach to localization of metal-ion-binding sites in the actin primary sites in the actin primary structure. Eur.J.Biochem. 182, 299-305.
  4. Strzelecka-Gołaszewska, H., Moraczewska, J., Khaitlina, S.Y., Mossakowska, M. (1993) Localization of the tightly bound divalent-cation-dependent and nucleotide-dependent conformational changes in G-actin using limited proteolytic digestion. Eur.J.Biochem. 211, 731-748.
  5. Khaitlina, S.Y., Moraczewska, J., Strzelecka-Gołaszewska, H. (1993) The actin-actin interactions involving the N-terminus portion of the DNaseI-binding-loop are crucial for stabilization of the actin filament. Eur.J.Bioch. 218, 911-920.
  6. Mossakowska, M., Moraczewska, J., Khaitlina, S.Y., Strzelecka-Gołaszewska, H. (1993) Proteolytic removal of three C-terminal residues of actin alters the monomer-monomer interactions. Biochem.J. 289, 897-902.
  7. Strzelecka-Gołaszewska, H., Mossakowska, M., Woźniak, A., Moraczewska, J., Nakayama, H. (1995) Long-range conformational effects of proteolytic removal of the last three residues of actin. Biochem.J. 307, 527-534.
  8. Moraczewska, J., Strzelecka-Gołaszewska, H., Moens, P.,D.,J., dos Remedios, C.G. (1996) Structural changes in subdomain 2 of G-actin observed by fluorescence spectroscopy. Biochem.J. 317, 605-611.
  9. Moraczewska, J., Wawro, B., Seguro, K., Strzelecka-Gołaszewska, H. (1999) Divalent  Cation-, and Polymerization-Dependent Changes in the Conformation of Subdomain 2 of Actin. Biophys.J. 77, 373-377.
  10. Moraczewska, J., Nicholson-Flynn, K., Hitchocock-DeGregori, S.E. (1999) The Ends of Tropomyosin Are Major Determinants of Actin Affinity and Myosin Subfragment 1-Induced Binding to F-Actin in the Open State. Biochemistry 38, 15885-15892.
  11. Moraczewska, J., Hitchcock-DeGregori, S.E. (2000) Independent Functions for the N- and C-termini in the Overlap Region of Tropomyosin. Biochemistry 39, 6891-6897.
  12. Borovikov Y.S., Moraczewska J., Khoroshev M.I., Strzelecka-Gołaszewska H. (2000) Proteolytic Cleavage of Actin Within the DNase-I-Binding Loop Changes the Conformation of F-actin and Its Sensitivity to Myosin Binding. Biochim. Biophys. Acta 1478, 138-151.
  13. Moraczewska, J., Greenfield, N.J., Liu, Y., Hitchcock-DeGregori, S.E. (2000) Alteration of Tropomyosin Function and Folding by a Nemaline Myopathy-Causing Mutation. Biophys. J. 79, 3217-3225.
  14. Hitchcock-DeGregori, S. E., Song, Y., Moraczewska, J. (2001) Importance of Internal Regions and the Overall Length of Tropomyosin for Actin Binding and Regulatory Function. Biochemistry 40, 2104-2112.
  15. Moraczewska, J., Gruszczyńska-Biegała, J., Rędowicz M.J., Khaitlina, S., Strzelecka-Gołaszewska, H. (2004) The Dnase-I Binding Loop May Play a Role in the Regulation of Actin-Myosin Interaction by Tropomyopsin/Troponin. J.Biol.Chem. 279, 31197-31204.
  16. Kłopocka ,W., Moraczewska, J., Rędowicz, M.J. (2005) Characterization of Rac/PAK pathway in Amoeba proteus. Protoplasma, 225, 77-84.
  17. Śliwińska M., Skórzewski R., Moraczewska J. (2008) Role of Actin C Terminus in Regulation of Striated Muscle Thin Filament. Biophys. J.94, 1341-1347.
  18. Skórzewski, R., Śliwińska, M., Borys, D., Sobieszek, A., Moraczewska J. (2009) Effect of actin C-terminal modification on tropomyosin isoforms binding and thin filament regulation. Biochim.Biophys. Acta – Prot. Proteom. 1794, 237-243.
  19. Skórzewski R, Robaszkiewicz K, Jarzębińska J, Suder P, Silberring J, Moraczewska J. (2009) Differential binding of tropomyosin isoforms to actin modified with m-maleimidobenzoyl-N-hydroxysuccinimide ester and fluorescein-5-isothiocyanate. Anal Biochem. 1; 394: 48-55.
  20. Śliwińska M., Żukowska M., Borys D., Moraczewska J. (2011) Different positions of tropomyosin on actin filament are determined by specific overlaps of end-to-end overlaps. Cytoskeleton 68, 300-312.
  21. Robaszkiewicz K., Dudek E., Kasprzak, A.A., Moraczewska J. (2012) Functional effects of congenital myopathy related mutations in gamma-tropomyosin gene. Biochim.Biophys.Acta - Mol. Basis Dis.1822, 1562-1569.
  22. Jurewicz E., Ostrowska Z., Jóźwiak J., Rędowicz M.J., Leśniak W., Moraczewska J., Filipek A. (2013) CacyBP/SIP as a novel modulator of the thin filament. Biochim. Biophys. Acta – Mol. Cell Res. 1833, 761-766.
  23. Jędrzejewska B, Bajorek A, Moraczewska J. (2013) Interaction of carbocyanine dyes with DNA: synthesis and spectroscopic studies. Appl. Spectrosc. 67 (6):672-80.
  24. Śliwińska M, Moraczewska J. (2013) Structural differences between C-terminal regions of tropomyosin isoforms. PeerJ. Oct 15;1:e181.
  25. Robaszkiewicz K., Ostrowska Z., Cyranka-Czaja A., Moraczewska J. (2015) Impaired tropomyosin-troponin interactions reduce activation of the actin thin filament Biochim.Biophys. Acta – Prot. Proteom.1854, 381-390.
  26. Robaszkiewicz K, Ostrowska Z, Marchlewicz K, Moraczewska J. (2016) Tropomyosin isoforms differentially modulate the regulation of actin filament polymerization and depolymerization by cofilins. FEBS J. 283(4):723-737.
  27. Borovikov YS, Rysev NA, Chernev AA, Avrova SV, Karpicheva OE, Borys D, Śliwińska M, Moraczewska J. (2016) Abnormal movement of tropomyosin and response of myosin heads and actin during the ATPase cycle caused by the Arg167His, Arg167Gly and Lys168Glu mutations in TPM1 gene. Arch Biochem Biophys. 606:157-166.
  28. Ostrowska Z, Robaszkiewicz K, Moraczewska J. (2017) Regulation of actin filament turnover by cofilin-1 and cytoplasmic tropomyosin isoforms. Biochim Biophys Acta – Prot. Proteom. 1865: 88-98 (doi: 10.1016/j.bbapap.2016.09.019).
  29. Borovikov YS, Rysev NA, Avrova SV, Karpicheva OE, Borys D, Moraczewska J. (2016) Molecular mechanisms of deregulation of the thin filament associated with the R167H and K168E substitutions in tropomyosin Tpm1.1. Arch Biochem Biophys. pii: S0003-9861(16)30557-4.(doi: 10.1016/j.abb.2016.12.004).
  30. Karpicheva OE, Sirenko VV, Rysev NA, Simonyan AO, Borys D, Moraczewska J, Borovikov YS. (2017) Deviations in conformational rearrangements of thin filaments and myosin caused by the Ala155Thr substitution in hydrophobic core of tropomyosin. Biochim Biophys Acta – Prot. Proteom. 1865 (12):1790-1799
  31. Simonyan AO, Sirenko VV, Karpicheva OE, Robaszkiewicz K, Śliwinska M, Moraczewska J, Krutetskaya ZI, Borovikov YS. (2018) The primary cause of muscle disfunction associated with substitutions E240K and R244G in tropomyosin is aberrant behavior of tropomyosin and response of actin and myosin during ATPase cycle. Arch Biochem Biophys. 644:17-28.
  32. Śliwinska M, Robaszkiewicz K, Czajkowska M, Zheng W, Moraczewska J. (2018) Functional effects of substitutions I92T and V95A in actin-binding period 3 of tropomyosin. Biochim Biophys Acta. – Prot. Proteom. 1866 (4): 558-568.
  33. Moraczewska J, Robaszkiewicz K, Śliwinska M, Czajkowska M, Ly T, Kostyukova A, Wen H, Zheng W. (2019) Congenital myopathy-related mutations in tropomyosin disrupt regulatory function through altered actin affinity and tropomodulin binding. FEBS J. 286(10):1877-1893. doi: 10.1111/febs.14787.
  34. Ostrowska-Podhorodecka Z, Śliwinska M, Reisler E. Moraczewska J (2020) Tropomyosin Isoforms Regulate Cofilin 1 Activity by Modulating Actin Filament Conformation. Arch Biochem Biophys 682, 108280, DOI: 10.1016/j.abb.2020.108280
  35. Jurewicz E, Robaszkiewicz K, Moraczewska J, Filipek A. (2020) Binding of S100A6 to actin and the actin-tropomyosin complex. Sci Rep. 10 (1):12824. doi: 10.1038/s41598-020-69752-y.
  36. Robaszkiewicz K, Śliwinska M, Moraczewska J. (2020) Regulation of Actin Filament Length by Muscle Isoforms of Tropomyosin and Cofilin. Int J Mol Sci. 21 (12):4285; https://doi: 10.3390/ijms21124285
  37. Śliwinska, M., Robaszkiewicz, K., Wasąg, P., Moraczewska, J. (2021) Mutations Q93G and E97K in TPM2 disrupt Ca-dependent regulation of actin filaments. Int J Mol Sci. 22(8), 4036; doi.org/10.3390/ijms22084036
  38. Robaszkiewicz K., Jurewicz E., Moraczewska J., Filipek A. (2021) Ca2+-dependent binding of S100A6 to cofilin-1 regulates actin filament polymerization-depolymerization dynamics. Cell Calcium 99:102457. doi: 10.1016/j.ceca.2021.102457
  39. Kuruba B., Kaczmarek M., Kęsik-Brodacka M., Fojutowska M., Śliwinska M., Kostyukova A., Moraczewska J. (2021) Structural Effects of Disease-Related Mutations in Actin-Binding Period 3 of Tropomyosin. Molecules 26 (22) 6980
  40. Katarzyna Robaszkiewicz, Małgorzata Siatkowska, Renske I Wadman, Erik-Jan Kamsteeg, Zhiyong Chen, Ashirwad Merve, Matthew Parton, Enrico Bugiardini, Charlotte de Bie, Joanna Moraczewska(2023)A Novel Variant in TPM3 Causing Muscle Weakness and Concomitant Hypercontractile Phenotype. Int J Mol Sci 24 (22): 16147. doi: 10.3390/ijms242216147.
  41. Katarzyna Robaszkiewicz, Julia Wróbel, Joanna Moraczewska(2023) Troponin and a Myopathy-Linked Mutation in TPM3 Inhibit Cofilin-2-Induced Thin Filament Depolymerization. Int J Mol Sci 24(22):16457. doi: 10.3390/ijms242216457.
  42. Recep Küçükdogru, Peter Franz, Remigiusz Worch, Katarzyna Robaszkiewicz, Małgorzata Siatkowska, Georgios Tsiavaliaris, Joanna Moraczewska (2024) Mechanochemical consequences of myopathy-linked mutations in Tpm2.2 on striated muscle contractility. FASEB J 38(1):e23400. doi: 10.1096/fj.202301604R.
 Artykuły przeglądowe:
  1.  Moraczewska, J. (2001) Tropomiozyna – regulatorowe białko filamentu cienkiego. Kosmos, 50, 236-270.
  2. Moraczewska, J. (2002) Structural determinants of cooperativity in acto-myosin interactions. Acta Biochim.Pol. 49 (4), 805-812.
  3. Moraczewska J. (2009) Rola izoform tropomiozyny w różnicowaniu funkcji filamentów aktynowych. Post. Bioch. 55: 201-206.
  4. Robaszkiewicz K., Moraczewska J. (2011) Wrodzone miopatie – choroby mięśni szkieletowych związane z zaburzeniami struktury i funkcji filamentu aktynowego. Post.Hig.Med.Dośw., 65, 347-356.
  5. Moraczewska J. Śliwińska M., Rędowicz M.J. (2012) Udział jonów wapnia w regulacji oddziaływań aktyny z miozyną. Post. Bioch. 58, .437-451.
  6. Ostrowska Z., Moraczewska J. (2017) Kofilina – białko kontrolujące dynamikę filamentów aktynowych. Post.Hig.Med.Dośw. 1865:88-98.
  7. Moraczewska J. (2018) Filamenty cienkie i mikrofilamenty – funkcjonalne kompleksy aktyny z tropomiozyną. Kosmos 67 (1), 31-41.
  8. Moraczewska J. (2020) Thin filament dysfunctions caused by mutations in tropomyosin Tpm3.12 and Tpm1.1. J Muscle Res Cell Motil., 41 (1), 39-53. doi: 10.1007/s10974-019-09532-y.
Sprawozdania z konferencji
  1. Moraczewska J. (2013) FEBS Constituent Society Meetings: FEBS National Lectures, FEBS News 3, 21.
  2. Rędowicz MJ, Moraczewska J. (2015) Insight into muscle physiology through understanding mechanisms of muscle pathology. J Muscle Res Cell Motil. 36(6):359-361.
  3. Rędowicz M.J., Moraczewska J. (2016) Sprawozdanie z 44th European Muscle Conference Warszawa, 21-25 września 2015r. Post. Bioch. 62: 21-24.
  4. Moraczewska J. (2022) First conference "Actin and actin-binding proteins in health and disease": Meeting report. Cytoskeleton (Hoboken). 2022 Dec 29. doi: 10.1002/cm.21739.

Inne

  1. Rędowicz MJ,Moraczewska J. (2020) Z aktyną i miozyną przez życie – wspomnienie o Profesor Hannie Strzeleckiej-Gołaszewskiej. Postępy Biochem. 66 (2):176-179.
  2. Joanna Moraczewska, Paul Trevorrow (2023) An interview with Joanna Moraczewska-Kazimierz Wielki University, Bydgoszcz, Poland. Cytoskeleton (Hoboken) 80 (5-6):95-97. doi: 10.1002/cm.21746.

 

prof. dr hab. Moraczewska Joanna